Python Job: Bioinformatician Immunology

Bioinformatician Immunology

Rijksinstituut voor Volksgezondheid en Milieu (RIVM)

Functieomschrijving

Are you an ambitious bioinformatician with a solid background in omics data analysis and experience in the field of immunology and/or infectious disease research? Then this bioinformatician position is the job for you!

Within our Center for Immunology of Infectious diseases and Vaccines we perform research on how vaccinations or infections protect against viruses and bacteria. We investigate the immunity gained after vaccination and/or infection with a special focus on the vulnerable groups in our society such as children and elderly. To this end, we investigate the immune mechanisms that protect us against disease caused by human pathogens. We use multiple "omics" approaches to characterize cellular immune responses in detail, in order to obtain biomarkers or immune profiles that correlate to protection against disease. Within the Center IIV several data-scientists are appointed, each with their own research focus.

Main responsibilities

• You will be involved in numerous projects aimed at understanding the immune response to vaccination and infection. You will be responsible for the implementation and design of data analysis workflows and pipelines. Your role will involve:
• Performing analysis of multi-omic research data (RNA-seq, scRNA-seq, ATAC-seq, proteomics, etc.), to integrate the outcomes with other clinical data and report findings.
• Being responsible for the analysis, processing and storage of large datasets conform best practices for ensuring analytical reproducibility
• Implement and design computational pipelines that allows answering specific questions related to immunology of infectious diseases and vaccines, such as identification of potential biomarkers related to immune protection or disease progression
• Visualization of the data analysis output into ‘state of the art’ figures
• Supporting data analysis for different projects within the department and training technicians/PhD students to use basic pipelines
• Contribute to academic research publications in collaboration with other team members

You will be appointed at:

The Center for Immunology of Infectious Diseases and Vaccines (IIV) at RIVM. This Center is the knowledge center of the government in the field of immunology of infectious diseases and vaccines. The core mission of this center is to provide information and advice about effectiveness of vaccines, vaccination strategies and immune responses against infectious diseases to parties within the government and to the general public. In support of this task, research performed at IIV is focused on optimization of the effectiveness of current and future vaccination programs, immunosurveillance, age-related efficacy of the immune responses and correlates of protection. In this work the center collaborates intensively with other RIVM knowledge centers and national and international collaborators specialized in immunology, microbiology, epidemiology and outbreak control of infectious diseases. Within the center IIV, the department Immune Mechanisms – Correlate of Protection (IMC) investigates the immune mechanisms that protect us against disease caused by human pathogens. The research is focused on characterizing cellular immune responses in detail, both the innate arm, as well as the adaptive arm. In various research projects we aim to obtain biomarkers or immune profiles that correlate to protection against disease.

Functie-eisen

Job requirements:

• You have a PhD degree in Bioinformatics, System Biology, Computational Biology, Biostatistics, Data Science or a related discipline requiring computational and strong statistical skills.
• Are able to perform data analysis in the field of biomedical sciences, with a robust publication track record preferably in the fields of immunology, infectious diseases and public health.
• Have ample experience with R and/or Python for bioinformatic research.
• Have experience in analyzing transcriptomic, proteomic and epigenomic large data sets, both in bulk and at a single cell level, preferably from studies in the field of immunology, infectious diseases and public health.
• Are result oriented, highly motivated, with a desire to learn and tackle new challenges and can work effectively both alone and in a team
• Can bridge different disciplines and know how to translate the results to address public health problems.
• Contribute to an open, stimulating and pleasant working environment and actively participate in scientific discussions.
• Excellent verbal, and written communication skills are essential in this collaborative and multi-disciplinary team environment.

Arbeidsvoorwaarden

Salarisniveau: schaal 10

Maandsalaris: Min €2.957 – Max. €4.707 (bruto)

Dienstverband: Arbeidsovereenkomst voor bepaalde tijd

Contractduur: Voor de duur van 12 maanden

Minimaal aantal uren per week: 32

Maximaal aantal uren per week: 36

Overige arbeidsvoorwaarden

Naast het salaris ontvang je een Individueel Keuzebudget (IKB). Het IKB bestaat uit geld (16,37% van je bruto jaarsalaris) en tijd. Met het IKB maak jij de keuzes die bij jou passen en kun je een deel van je arbeidsvoorwaarden zelf samenstellen. Je kunt er bijvoorbeeld voor kiezen om een deel van je maandinkomen te laten uitbetalen wanneer jij dat wenst. Ook kun je dit budget omzetten in verlof en andersom of besteden aan fiscaal vriendelijke doelen. De Rijksoverheid hecht sterk aan persoonlijke groei en loopbaanontwikkeling en biedt daarvoor tal van mogelijkheden. Tot de secundaire arbeidsvoorwaarden behoren onder meer verschillende studiefaciliteiten, bedrijfsfitness, volledige vergoeding van je OV-reiskosten woon-werkverkeer en gedeeltelijk betaald ouderschapsverlof.

Bijzonderheden

Please address your (digital) motivation letter to Dr. Jelle de Wit (head of the department IMC).

Solliciteren?

Rijksinstituut voor Volksgezondheid en Milieu (RIVM) nodigt je uit op hun site te solliciteren. Via onderstaande knop verlaat je deze site ga je direct naar het sollicitatieformulier. Het Rijk hecht waarde aan een diverse en inclusieve organisatie. Werken in divers samengestelde teams maakt ons effectiever, innovatiever en het werk leuker. Eenieder wordt daarom uitgenodigd te solliciteren.